The integration, powered by Button, enables customers to book an Uber to take them directly to their hotel, at the touch of a button.
Customers using the Hotels.com Android app can book the cab service in 30 different languages and in all countries that Uber operates in.
Users will see an Uber button appear in their app on the day their hotel stay begins, both on the homepage and in the reservation section.
When a user taps the ‘Ride there with Uber’ button, their current location and hotel address is automatically pre-populated within Uber’s app.
Dan Craig, senior director of mobile for Hotels.com, said: “At Hotels.com we pride ourselves on being at the forefront of mobile technology developments in the travel industry, so being one of the first OTAs to offer this Uber service is fantastic news.
“Like us, Uber are technology leaders in their field and together we’re making it easy for travellers to get to their hotel in a hassle-free way, so they can start their trip sooner.
“We’re always looking for ways to enhance our in-stay mobile offering, so watch this space for more exciting features coming soon.”
Chris Saad, head of product for the Uber developer platform, said: “We are always looking for ways to improve the end-to-end travel experience and now with the integration of Uber and Hotels.com through Button, exploring the world is even easier than ever.”